By what time after injury should TXA be administered at the latest?

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Multiple Choice

By what time after injury should TXA be administered at the latest?

Explanation:
TXA slows fibrinolysis to help stabilize clots in bleeding trauma. The key is timing: evidence shows a mortality benefit when TXA is given within 3 hours of injury, with the strongest benefit when administered as early as possible. Beyond 3 hours, the data do not demonstrate a clear survival benefit, so the recommended latest time to administer is no later than 3 hours after injury. In practice, TXA is given as soon as bleeding is suspected, with the usual regimen of 1 g IV over 10 minutes, then 1 g over 8 hours.

TXA slows fibrinolysis to help stabilize clots in bleeding trauma. The key is timing: evidence shows a mortality benefit when TXA is given within 3 hours of injury, with the strongest benefit when administered as early as possible. Beyond 3 hours, the data do not demonstrate a clear survival benefit, so the recommended latest time to administer is no later than 3 hours after injury. In practice, TXA is given as soon as bleeding is suspected, with the usual regimen of 1 g IV over 10 minutes, then 1 g over 8 hours.

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