In the TXA protocol, what is the recommended dose and route for administration?

• A. 2 g IV/IO slow push over 1 minute
• B. 1 g IV/IO over 5 minutes
• C. 2 g IM bolus
• D. 2 g IV/IO over 10 minutes

Answer: (A)

The main idea tested is how TXA should be dosed and given in the field to act quickly against bleeding. The protocol emphasizes a rapid, systemic antifibrinolytic effect, so the recommended plan is a 2-gram dose given IV or IO as a bolus over about one minute. This route and rate ensure the medicine reaches the bloodstream fast, achieving therapeutic levels quickly to help stabilize clots during the critical prehospital period. Intramuscular administration is slower and more variable in absorption, making it less reliable for this purpose, and delivering the dose over a longer time (such as ten minutes) would delay peak levels and reduce early efficacy. A 1-gram dose would be under the full protocol dose and may not provide the same antifibrinolytic impact.