What is the maximum total dose of Naloxone?

• A. 2 mg
• B. 4 mg
• C. 8 mg
• D. 10 mg

Answer: (D)

Naloxone dosing is given in small, titrated amounts to reverse opioid toxicity while avoiding unnecessary effects. The goal is to restore adequate breathing and mental status while minimizing withdrawal and sympathetic surge. In adults, you start with a small dose and give additional doses every few minutes until improvement. Although you may need multiple doses, most guidelines cap the total amount you give at about 10 mg. That limit balances effective reversal with reducing the risk of precipitating withdrawal, hypertension, tachycardia, or other adverse effects, and it takes into account that some opioids can outlast a single dose of naloxone. If symptoms return because the opioid effect lasts longer, you can repeat dosing or escalate care, but the practical maximum in many protocols remains around 10 mg.