Which of the following is also listed as a TXA indication?

• A. Evidence of severe bleeding
• B. No bleeding
• C. Chronic dehydration
• D. Fever

Answer: (A)

Tranexamic acid is used in trauma when there is evidence of severe bleeding to help reduce hemorrhage and improve outcomes. It works by inhibiting the breakdown of clots, stabilizing blood clots that are forming, which is most beneficial when bleeding is significant. For best effect, give it as early as possible, ideally within the first hour and certainly within about 3 hours of injury. In many field protocols, the dose is 1 g IV over 10 minutes, followed by 1 g IV over 8 hours. It’s not indicated if there isn’t active or suspected heavy bleeding, and it’s not used for conditions like dehydration or fever, which don’t involve bleeding that TXA can address.